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AstraZeneca buys cancer researcher KuDOS
AstraZeneca buys cancer researcher KuDOS
Date published:
23/12/2005
AstraZeneca has agreed to purchase British cancer researcher
KuDOS Pharmaceuticals for £121
million. KuDOS currently specialises in the discovery and development of cancer
treatments, based upon inhibiting the repair of DNA. AstraZeneca said that the
acquisition would improve the company's cancer medication portfolio.
AstraZeneca's record in cancer research was hampered in 2004 by the
failure of its drug Iressa to improve survival rates amongst individuals with
non-small cell lung cancer. Dr John Patterson, executive director of
development at AstraZeneca, said in a statement: "KuDOS Pharmaceuticals is an
excellent opportunity to acquire an established technology platform additive to
our own oncology research capabilities and promising early development stage
compounds at the same time."
KuDOS already has one compound, KU 59436,
undergoing phase I development. The drug inhibits poly-ADP-ribose polymerase
(PARP) enzymes, which work to repair damage to single strand DNA. By inhibiting
the enzyme, the KuDOS claims that tumour cells are killed whilst normal cells
are left unaffected.
AstraZeneca said that the company will become a
hub for research into DNA repair, and would report to its Global Cancer and
Infection Research Area, which already has sites in India, the US and the
UK.
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