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Home » Articles » Getting started » An Overview of the Pharmaceutical Industry In the UK

An Overview of the Pharmaceutical Industry In the UK



An Overview of the Pharmaceutical Industry In the UK

(Date published: 25 January 2002)

Stephen Gordan
UKPharm.com

The Pharmaceutical Industry is the second largest contributor to Gross Domestic Product behind Financial Services. There are several very big players in the UK with GlaxoWelcome, SmithKline Beecham and AstraZeneca being the three largest UK based companies. In America the largest organization (in capital terms) is Merck Sharp and Dohme (MSD), and until recently this was the worlds largest company. In recent years with the merger of Glaxo Welcome and Smithkline Beecham to form GSK, Merck Sharp & Dohme have been relegated to second position.

There are three distinct types of pharmaceutical companies in the UK:

  • Research and Development (An Integrated Company)
  • Research Only - i.e. Biotechnology
  • Contract Pharmaceutical Organization (CPO) i.e. Snyder and Ashfield

Within the CPO's there are two distinct types of field force:

Dedicated Sales Team
An integrated company works in partnership with a CPO over a prolonged period if time. The products promoted are solely those belonging to the integrated company. The advantages of this type of arrangement for you are numerous and include: a definite contract with the CPO even if the integrated company struggle, possibilities of working with numerous companies and developing your broad knowledge, possibility of been taken on head count in an organisation you like.

Syndicated Sales Team
These are managed by the CPO and you would sell up to three drugs from different companies. The advantages for you working in this environment include:
- Varied product and therapy area knowledge, which if you want to progress in to marketing would help immensely
- variety with little chance of boredom.
- Early promotional opportunities, as many CPOs look to develop their successful syndicated reps into higher positions within their organisations.

Pharmaceutical companies in the UK operate in a monopsonist market, in that, there is only one major purchaser (the NHS). Adding increasing challenge to this equation, this monopsonist is also the price regulator (the government) and therefore the one purchaser is also the price regulator. You could ask, why therefore does the government not slash all drug prices and reduce the costs of the NHS?

Within the NHS there are two distinct sectors:

Primary care
This constitutes General Practice i.e. GPs, Practice Nurses, Practice Managers and Health Authorities


Secondary Care
This includes Hospitals and all their associated infrastructure i.e. Consultants, Registrars, Junior Doctors, Pharmacy, Ward Staff and Specialist Nurses.

Generally speaking ten times more prescribing takes place in primary care, although it is important to recognise that much of this prescribing is Hospital led or instigated, with the General Practitioner often working in close cooperation with their hospital colleagues.

This Hospital influenced community prescribing practice is an important factor for Medical Representatives to take into account, although this balance has seen some change since the advent of Primary Care Groups (PCGs), set up by the new Labor Govt.

One important factor that PCG's are tasked to examine is the balance between the cost of prescribed medication versus provision of the best possible medical care. Of fundamental importance within this process is the agreement of drug forularies, where drug efficacy and relative costs are considered across all major therapy areas. The outcome is a 'prescribing guide', which all GP's within given PCG's, are encouraged to adhere to.

The impact of this policy can either have a positive or detrimental effect on the pharmaceutical products that your company promotes. If your drug fails to gain a formulary inclusion, then the Doctors ability to prescribe is limited.

In recent years the number one drug prescribed in the UK has been "Losec" by Astra Pharmaceuticals. At its height, Losec sales amounted to one million pounds per day! Losec loses it's patent in 2001, meaning that other Pharmaceutical companies will be allowed to manufacture it. They will have to call it Omeprazole (its GENERIC name) but with no research and development costs (R+D) involved the new companies will be able to massively undercut the BRANDED version, Losec. It is envisaged that all PCGs will switch their prescribing of Losec to Omeprazole, resulting in reducing revenues for Astra. Astra have therefore developed new drugs, with patents, to make up for this shortfall in earnings.

Drug representatives in the main sell prescription only medicines (POMs). This means that they influence the Doctor to prescribe their drug. The patient then takes the prescription the chemist, who dispenses the drug. At the end of every month the number of prescriptions dispensed by each chemist for each drug is totaled up. All chemists who work in a specific postal brick add together their figures to give a total number of prescriptions per postal brick per product. Every Representative works designated postal bricks so these figures constitute actual territory sales and are termed RSA (Regional Sales Analysis).

A representative does not directly sell drugs to a Doctor but encourages him to write their product on a prescription (called an FP10). The exception to this is the field of Vaccines, where a DR can buy the injections from the company direct.

The representative rarely sells directly to the chemist either. Normally when a prescription comes into a chemist via the patient, the chemist will take a pack off the shelf and re order a new pack direct from the wholesaler. The exceptions are:

  • Some companies offer discounts to the chemist if they place an order directly with the rep. This often happens with generics where cost is the key driver.
  • Over the counter (OTC) medicine. These are products that were once POM and can now be bought from your chemist i.e. Ibuprofen. A company will generally have a different team of Representatives to sell OTC medications.

On an average territory you can expect to find between 60 - 80 GP representatives.


Types of Medical Representative

Broadly speaking, there are four distinct types of Pharmaceutical Representative.

Part Time Medical Representative
Generally works from 8am - 1/2pm in Primary Care, with a very small amount of evening work.

Full Time Medical Representative
Primary Care only - Works only with GPs, practice nurses and practice managers, possibly some Health Authority.

Full Time GP/Hospital Representative
Works in primary care in the morning and secondary care in the afternoon.

Hospital Specialist
100% dedicated to hospitals. This role is one that can only be done after spending time in Primary Care first.


As well as the above, there exists a wide variety of specialist and project driven Medical Representatives, for example, the advent of PCG's has seen the emergence of Specialist PCG Representatives, whose remit it is to understand the influence PCG policy and decision making.

Over the last ten years or so the number one problem facing the representative is gaining access to prescribers and influencers. Healthcare professionals time has become increasingly busy and the representative runs a constant gauntlet, where he is competing for time with numerous other distractions.

Couple this with the shift towards generic prescribing and the role of the representative is a tough one.

With the average cost of initially getting a new representative selected, trained and out on the road for one year estimated to be at TWO HUNDRED THOUSAND POUNDS, you can see why companies do not want to make any mistakes.

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